• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Procedure for obtaining implants with customized surface, comprising the cleaning/activation of the surface of the implant by plasma technology, using oxygen plasma or argon, obtaining surfaces without any organic compound or oxide layer, and the application of a liquid solution that is specific for each patient and that carries osteoconductive, osteoinductive, antiobiotic, antibacterial or probiotic components, separately or jointly. The cleaning/activation of the implant surface using plasma technology can be carried out in the clinic or in the implant manufacturing plant, and the application of the liquid solution is carried out in the dental clinic, just before the intervention for implant placement. (Machine-translation by Google Translate, not legally binding)
    公开号:ES2579979A1
    申请号:ES201431805
    申请日:2014-12-09
    公开日:2016-08-18
    发明作者:Fernando Mozo Grau
    申请人:Fermoinvers S L；Fermoinvers SL；
    IPC主号:
    专利说明:

     2 DESCRIPTION PROCEDURE FOR OBTAINING IMPLANTS WITH PERSONALIZED SURFACE 5 OBJECT OF THE INVENTION The invention, as set forth in the present specification, refers to a procedure for obtaining implants with a personalized surface. 10 More particularly, the object of the invention is focused on a process whose purpose is to obtain an implant whose surface is treated in a personalized manner for each need, consisting essentially of cleaning / activation by means of plasma technology for ensure that the surface of the implant is clean and chemically receptive, and in the application of a fluid solution of a different nature, for example osteoinductive, osteoconductive, antibiotic, probiotic or antibacterial, according to the specific needs of each patient, essentially for the purpose of achieve 20 accelerate osseointegration in dental implantology and increase BIC (bone Implant contact) values between the bone and the implant. FIELD OF APPLICATION OF THE INVENTION 25 The field of application of the present invention is framed within the dentistry sector, focusing particularly on the field of3 implants. BACKGROUND OF THE INVENTION As it is known the treatment of deficiencies in dental pieces with 5 implants is well known as a reliable solution and with high success rates. However, there are situations in which due to deficiencies, medical treatments or pathologies of the patient themselves, the implant treatment has to be ruled out or with little expectation of success. The objective of the present invention is therefore to develop a procedure to be able to treat in a personalized way the surfaces of these implants in order to correct these deficiencies or to treat the pathologies of each patient to avoid rejections and increase the success rate of this treatment. in the short, medium and long term, as well as avoiding possible diseases in the tissues around the implant. On the other hand, it is also known that by applying oxygen, argon or helium plasma, surfaces of certain materials can be cleaned / activated, obtaining surfaces with radicals in which products react, facilitating adhesion. However, as a reference to the current state of the art, at least on the part of the applicant, it is unknown the existence of any other procedure that applies said plasma technology to the implants and, therefore, that presents technical characteristics similar to those4 which is presented here, as claimed. EXPLANATION OF THE INVENTION As noted above, what the invention proposes is a procedure for obtaining dental implants with a personalized surface by means of plasma technology, surfaces are obtained without any organic compound or oxide layer and fully activated to which, subsequently, a fluid solution is applied which, depending on the needs of each patient, may be; 10 osteoinductive, osteoconductive, antibiotic, probiotic or antibacterial. This process, preferably, is carried out in the dental clinic itself, moments before the intervention for implant placement, although, at least the initial step of cleaning the implant 15 by means of plasma technology, it can be carried out at the implant manufacturing plant. In any case, the personalization through fluid solutions with bone inducing components, bone conductive components or with antibiotic, antibacterial or probiotic solutions, will be applied in the clinic itself and its selection will be carried out 20 based on the patient's needs to ensure successful osseointegration of the implant. The objective of the invention thus focuses on the process of personalization of the surface of the implants by means of cleaning / activation by plasma technology and the subsequent application of a specific fluid solution for each patient. BlissThe solution will already have the components osteoconductors, osteoinductors, antiobiotics, antibacterials or probiotics, separately or together, depending on the needs of the patient. As noted, the solution is applied to the implant once the cleaning and surface activation is finished using plasma technology. Once said cleaning / activation process is completed, the vial is applied with the fluid solution to the implant, being in its corresponding vial, and in a short period of time the surface of the implant will be customized for said patient. 10 Specifically, then, the recommended method essentially comprises cleaning / activating the surface of the implant by means of plasma technology so that it is chemically receptive and, consequently, suitable for application on it of a fluid solution that It will be specific in each patient according to their needs. More specifically, the object of the invention is the cleaning / activation of the implant surface by using oxygen plasma or argon to drag all organic and contaminant debris including the oxide layer, innate in the implant, and activate said surface. creating places with radicals to obtain a highly reactive surface to which to apply the customized fluid solution and which, due to the reactivity of the surface, will be completely impregnated in the implant, 25 making its personalized behavior effective.6 By customizing the surface of the implants, based on the biological characteristics of each patient, the success rate will increase substantially in the short, medium and long term, since it is possible to accelerate osseointegration in dental implantology and increase BIC values (bone Implant contact) between the bone and the implant. Cleaning / activating surfaces by using oxygen or argon plasma is known to be a very effective cleaning / activation. Due to the effectiveness of its process we obtain a highly reactive surface that allows the application of the customized fluid solution. DETAILED EXHIBITION OF AN EMBODIMENT 15 Once the case is planned, that is, after studying the biology of the patient's maxillary bone, their habits, background and analyzing the possible surgical trauma of the patient, and based on the data obtained, we will apply The surface of the implant and with the aim of increasing the BIC values (Bone Implant Contact, bone-20 implant contact) the fluid, in a simple or combined way, and which can be: osteoinductor, osteoconductor, antibacterial, antibiotic or probiotic. To ensure that said fluid penetrates all micro-pores of the implant surface, cleaning / activation is performed prior to said implant by means of plasma cleaning / activation technology, obtaining a surface without the innate oxide layer in the7 titanium on contact with air and, therefore, highly reactive, thus achieving that the correction / enhancer fluid is perfectly impregnated on the entire surface of the implant. Normally, dental implants are supplied sterile. The 5 packaging of the dental implant consists of: the implant inserted in a vial and this in turn introduced in a blister and sealed with airtightness to maintain sterility. Thus, once the patient data is obtained regarding their type of bone, biology, background and habits that can influence the correct osseointegration, the fluid will be chosen, with the simple or combined compound, which is more appropriate to your case and which, therefore, will be an osteoinductive compound, or an osteoconductive compound, or an antibiotic compound, or an antibacterial compound or a probiotic compound or a compound that combines a mixture of any of the aforementioned compounds. More particularly, the types of fluid used, as well as their composition and quantity, depending on the different pathologies that patients may present will preferably be the following: - Probiotic Fluid: Promotes the favor of non-flora pathogenic Amount of Fluid: Ampoules of 2.5 cm3 to 5 cm3 25 Composition: Fluid consisting mainly of Lactobacillus or similar.8 Patient Pathologies: - Osteopenia - Hyperparathyroidism. - Antibiotic Fluid: Promotes the inhibition of collagens and 5 of protein synthesis. Amount of Fluid: Ampoules of 2.5 cm3 to 5 cm3 Composition: Fluid consisting mainly of Tetracycline, Terramycin or similar Patient Pathologies: 10 - Decontaminants. - Prevention of periodontal and / or peri-implant recurrences. - Immune problems. 15 - Osteoinductor fluid: Promotes bone formation. Amount of Fluid: Ampoules of 2.5 cm3 to 5 cm3 Composition: Fluid of human origin (patient or donor), consisting mainly of 20 Stem Cells, platelet growth factors or morphogenetic proteins. Patient Pathologies: - Acute osteoporosis. - Treatments with Chemotherapy or Radiation Therapy. - Bone mineralization diseases.9 - Osteoconductive fluid: Promotes the maintenance of a vital space for bone formation. Amount of Fluid: Ampoules of 2.5 cm3 to 5 cm3 Composition: Fluid consisting mainly of Hydroxyopatite and Tricalcium Phosphates. 5 Patient Pathologies: - Extractions of dental pieces and immediate implant placement. - Cystic cavities (bone defects) - Defects that complicate the healing of bone tissue. Preferably, at the time of surgery the implants that are to be placed in said patient are subjected to the plasma cleaning / activation process, said process takes no more than 15 15 minutes. To do this, you must open the sealed blister and remove the vials with the implants and insert them into the plasma machine. This plasma cleaning consists of different phases. First, the ultraviolet light generated in the plasma breaks and lifts most of the 20 organic adhesives and surface contaminants. The entrained surface particles react chemically with the oxygen ions of the plasma, producing other molecules such as water and carbon dioxide that are extracted from the chamber by the vacuum system. In the plasmas generated for the cleaning of oxidizable metals in which there is no oxygen, the particles removed from the surface are directly extracted outside the chamber to avoid10 material redepositions, leaving the surface ultra clean and ready to be adhered. Once the programmed cycle is finished, the vials are removed, with the implants inside and the cap is removed from the vial. Without extracting the implants from the vial, the planned sterile fluid is poured into the vial, to reduce the possible deficiencies and / or enhance the biological virtues of the patient, in order to obtain an increase in BIC values and, therefore, improve the osseointegration of the implant with the bone of said specific patient. 10 Next, the implants are placed in the patient in a conventional manner. Describing sufficiently the nature of the present invention, as well as the way of putting it into practice, it is not considered necessary to extend its explanation so that any expert in the field understands its scope and the advantages that derive from it, stating that , within its essentiality, may be implemented in other embodiments that differ in detail from that indicated by way of example, and to which it will also achieve the protection that is sought provided that it is not altered, changed or modified fundamental principle. 25 
    权利要求:
    Claims (1)
    [1]
    11 R E I V I N D I C A C I O N E S 1.- PROCEDURE FOR OBTAINING IMPLANTS WITH A CUSTOMIZED SURFACE, characterized in that it comprises the following steps: 5 - cleaning / activation of the surface of dental implants by using oxygen or argon plasma; - application of a fluid solution that is specific for each patient. 2.- PROCEDURE FOR OBTAINING IMPLANTS WITH A PERSONALIZED SURFACE, according to claim 1, characterized in that the fluid solution contains osteoconductive, osteoinductive, antiobiotic, antibacterial or probiotic components, separately or jointly. 3.- PROCEDURE FOR OBTAINING IMPLANTS WITH A PERSONALIZED SURFACE, according to claim 1 or 2, characterized in that the cleaning / activation of the implant surface 20 by means of oxygen or argon plasma and the application of the fluid solution is carried out in the dental clinic, moments before the intervention for the implant placement. 4.- PROCEDURE FOR OBTAINING IMPLANTS WITH 25 PERSONALIZED SURFACE, according to claim 1 or 2, characterized in that the cleaning / activation of the implant surface12 using oxygen or argon plasma is carried out in the implant manufacturing plant and the application of the fluid solution is carried out in the dental clinic, moments before the intervention for implant placement. 5
    类似技术:
    公开号 | 公开日 | 专利标题
    KR101445819B1|2014-09-29|UV irradiation system for the recovery of surface activity of aged dental implants
    KR20160081880A|2016-07-08|Dental implant package for enhancing bioactivity of implant surface and Packaging method
    KR20160058071A|2016-05-24|Dental implant package for enhancing bioactivity of implant surface and Packaging method
    BR112017020326A2|2018-11-27|artificial salivary gland
    ES2579979B1|2017-07-07|Procedure for obtaining implants with a personalized surface
    JP6105043B2|2017-03-29|Device for treating peri-implantitis
    ES2323628T3|2009-07-22|MATERIAL TO CONTROL ORGANISMS AND FOR THE SELECTIVE ADSORTION OF PROTEINS, CEMENT AND BIOMATERIAL.
    Kanno et al.2012|Novel denture-cleaning system based on hydroxyl radical disinfection.
    KR101359100B1|2014-02-05|Method for treating the surface of implant fixture
    KR20160116100A|2016-10-07|Method coating of fixture implant
    JP3203603U|2016-04-07|UV irradiation equipment
    RU2593817C2|2016-08-10|Method of accelerating process of reparative osteogenesis
    CN203677575U|2014-07-02|Nasal endoscope disinfecting device
    Jo et al.2015|Effects of various treatments for contaminated implants
    de Souza RESENDE et al.2014|Treatment of peri-implantitis and guided bone regeneration associated with autogenous bone: A case report.
    JP2020515534A|2020-05-28|Powder for cleaning body parts and/or implants, process for producing said powder and suitable use
    Nicolucci2013|Peri-implantitis: treatment options
    EA201790382A1|2017-08-31|METHODS OF TREATMENT OF PERIIMPLANTITA
    US11103657B2|2021-08-31|Systems and methods for reducing contaminants in a portion of a patient
    RU2560508C1|2015-08-20|Method for saturation of porous coating of prosthetic implants
    WO2016065684A1|2016-05-06|Method for maintaining bone morphogenetic protein-2 activity under the irradiation sterilization conditions
    KR20160057714A|2016-05-24|Dental implant package for enhancing bioactivity of implant surface and Packaging method
    MD3724G2|2009-05-31|Method for treating herpetic stomatitis of medium and severe degree
    CN203075285U|2013-07-24|Pathogenic bacteria killer
    KR20120102237A|2012-09-18|Manufacturing apparatus of bone grafting material
    同族专利:
    公开号 | 公开日
    RU2017118186A3|2019-03-20|
    ES2579979B1|2017-07-07|
    EP3243479B1|2020-03-04|
    US20170319300A1|2017-11-09|
    WO2016092130A1|2016-06-16|
    MX2017007486A|2018-05-04|
    EP3243479A4|2018-09-19|
    RU2017118186A|2019-01-11|
    ES2810808T3|2021-03-09|
    EP3243479A1|2017-11-15|
    CN106999262A|2017-08-01|
    RU2701560C2|2019-09-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US5071351A|1986-07-02|1991-12-10|Collagen Corporation|Dental implant system|
    SE500657C2|1992-12-07|1994-08-01|Nobelpharma Ab|Method and apparatus for preparing implant surfaces using gas discharge plasma|
    US6033582A|1996-01-22|2000-03-07|Etex Corporation|Surface modification of medical implants|
    US6214049B1|1999-01-14|2001-04-10|Comfort Biomedical, Inc.|Method and apparatus for augmentating osteointegration of prosthetic implant devices|
    AR022333A1|1999-01-26|2002-09-04|Anitua Aldecoa Eduardo|OSEO FABRIC REGENERATOR|
    ES2179731B1|2000-04-14|2004-04-16| Alberto Arruga Artal|DENTAL IMPLANT AND OPERATIONAL IMPLEMENTATION METHOD.|
    CH694935A5|2000-07-26|2005-09-30|Straumann Holding Ag|Oberflaechenmodifizierte implants.|
    PL205705B1|2000-09-19|2010-05-31|Aldecoa Eduardo Anitua|Method for surface treatment of implants or prosthesis made of titanium or other materials|
    DE10324415A1|2003-05-28|2004-12-16|Blue Membranes Gmbh|Coating procedure for coating substrates with carbon based material, comprises carbonation of polymer film in oxygen free environment at temperature ranging from 200 to 2500 degrees Celsius|
    RU2330685C2|2005-07-12|2008-08-10|Александр Юрьевич Базаров|Method of antibiotics fixation within porous implants|
    US20080292779A1|2007-05-22|2008-11-27|Mercuri Gregory M|Coating of implants with hyaluronic acid solution|
    WO2009147166A1|2008-06-06|2009-12-10|Thommen Medical Ag|Package for dental implant|
    JP5878369B2|2008-08-07|2016-03-08|エクソジェネシス コーポレーション|Medical device for bone implant and method of manufacturing the device|
    DE102011001401A1|2010-12-20|2012-06-21|Frank-Peter Spahn|Crestal implant and method for its processing|
    WO2013040469A1|2011-09-15|2013-03-21|Cold Plasma Medical Technologies, Inc.|Harmonic cold plasma devices and associated methods|
    WO2014007959A1|2012-07-02|2014-01-09|Icon Medical Corp.|Improved metal alloy for medical devices|
    KR101311990B1|2013-07-18|2013-09-27|오스템임플란트 주식회사|Implant coating material for enhancing a bioactivity and osseointegration of implant surface, and the method for manufacturing and storing the same|CN108836530A|2018-07-09|2018-11-20|柏娜|A kind of dental implant processing method rapidly promoting dental implant in conjunction with alveolar bone|
    法律状态:
    2017-07-07| FG2A| Definitive protection|Ref document number: 2579979 Country of ref document: ES Kind code of ref document: B1 Effective date: 20170707 |
    优先权:
    申请号 | 申请日 | 专利标题
    ES201431805A|ES2579979B1|2014-12-09|2014-12-09|Procedure for obtaining implants with a personalized surface|ES201431805A| ES2579979B1|2014-12-09|2014-12-09|Procedure for obtaining implants with a personalized surface|
    CN201580067232.1A| CN106999262A|2014-12-09|2015-12-02|The process of implant of the production with personalized surface|
    US15/527,450| US20170319300A1|2014-12-09|2015-12-02|Procedure for producing implants with a personalised surface|
    RU2017118186A| RU2701560C2|2014-12-09|2015-12-02|Method of producing implant with personified surface|
    EP15867442.4A| EP3243479B1|2014-12-09|2015-12-02|Method for producing implants with a personalised surface|
    ES15867442T| ES2810808T3|2014-12-09|2015-12-02|Procedure to obtain implants with a personalized surface|
    PCT/ES2015/070871| WO2016092130A1|2014-12-09|2015-12-02|Method for producing implants with a personalised surface|
    MX2017007486A| MX2017007486A|2014-12-09|2015-12-02|Method for producing implants with a personalised surface.|
    [返回顶部]